This paper presents the details of a quantitative method for the determination of the sugar tolerance or better "assimilation limit"; its standardization with groups of normal controls, and the results of its application to a large group of cases presenting a variety of disease conditions. Certain portions of this work have already appeared,1 and this article summarizes these and the later portions of the study.
The earlier method of determining the assimilation limit by the oral administration of graded doses of sugar and the examination of the urine for the appearance of a melituria was standardized by Hofmeister2 in a series of experiments with dogs. He demonstrated that (a) the ingestion of an excess of a given sugar above the assimilation capacity of the individual will produce a transitory appearance of sugar in the urine; (b) the amount producing this melituria is a constant for the individual with
ROWE AW. SUGAR TOLERANCE AS AN AID TO DIAGNOSIS. JAMA. 1927;89(17):1403–1407. doi:10.1001/jama.1927.02690170027009