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JAMA Clinical Guidelines Synopsis
April 12, 2016

Management of Atopic Dermatitis

Author Affiliations
  • 1Section of Dermatology, University of Chicago, Chicago, Illinois
  • 2Section of General Medicine, University of Chicago, Chicago, Illinois
JAMA. 2016;315(14):1510-1511. doi:10.1001/jama.2016.1459

Atopic dermatitis is a chronic inflammatory skin disorder affecting approximately 10% of US adults and children.1,2 The condition is the result of multiple factors including a hyperstimulated cutaneous immune system, a genetically determined compromised skin barrier, and exposure to triggering environmental stimuli. Flares manifest as extreme pruritus of red, rough, flaky and often fissured regions of the skin that become chronically thickened, rough, and discolored. Atopic dermatitis can have a profound effect on the quality of life of patients and their families through effects on sleep, behavior, mood, and absences from school and work.3 The topical therapies discussed in this guideline4 are considered the first line of management.

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