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Comment & Response
April 12, 2016

Acute Kidney Injury With Buffered Crystalloids vs Saline Among ICU Patients

Author Affiliations
  • 1Khoo Teck Puat Hospital, Anaesthesia and Surgical Intensive Care, Singapore
JAMA. 2016;315(14):1519. doi:10.1001/jama.2016.0142

To the Editor The SPLIT trial1 tested the hypothesis that using Plasma-Lyte 148 instead of saline for intravenous fluid therapy would decrease the risk of AKI among patients in the ICU. Data have been accumulating based on animal and human studies that saline may be associated with AKI.2 A recent open-label prospective sequential study showed that use of chloride-restricted, balanced salt solutions in patients who are critically ill may be associated with lower incidence of AKI.3

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