October 4, 1941


Author Affiliations

San Francisco.

JAMA. 1941;117(14):1204. doi:10.1001/jama.1941.02820400062024

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To the Editor:—  In The Journal, April 26, in an article on "chronic sinusitis," F. M. Turnbull recommends the use of 5 per cent sodium sulfathiazole for local treatment. As a result, many general physicians and ear, nose and throat specialists are being requested to use this drug in the treatment of chronic as well as acute sinusitis. The following report indicates that the local use of sodium sulfathiazole, or in fact the use of any sodium salt of sulfanilamide, may be extremely dangerous in the treatment of sinusitis:A woman had a foul purulent infection in the left antrum following the extraction of a tooth. There was some osteomyelitis in the area of the tooth socket, where there was a fistula. The teeth adjacent to the fistula were loose and the bone about the roots was involved. There was a large, loose sequestrum in the fistula. The discharge was

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