The beneficial effects of intravenous injections of dextrose in conjunction with the radiation treatment of malignant disease were suggested to us in a personal communication from Professor Holzknecht of Vienna in March, 1926.
It was believed by Professor Holzknecht and his associate, Dr. Mayer, that tumor tissue seemed to be rendered more sensitive to radiation when the latter was combined with the intravenous injections of a hypertonic solution of dextrose, and that the clinical improvements were especially striking in those cases which were found to be refractory to radiation alone. It was further observed by them that the intensity of the so-called constitutional effects of radiation, or radiation sickness, was greatly diminished or prevented. He gave us these suggestions so that we might make further investigations along the same line.
Dr. Ernest G. Mayer, working under the direction of Professor Holzknecht, gave the first account of his experience in an
PFAHLER GE, WIDMANN BP. VALUE OF INTRAVENOUS INJECTIONS OF DEXTROSEDURING RADIATION TREATMENT OF MALIGNANT DISEASE. JAMA. 1927;89(18):1492–1496. doi:10.1001/jama.1927.02690180024007