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Comment & Response
April 19, 2016

Exercise Intensity, Dose, and Cardiovascular Disease—Reply

Author Affiliations
  • 1Department of Physiology, Radboud University Medical Center, Nijmegen, the Netherlands
  • 2Division of Cardiology, Hartford Hospital, Hartford, Connecticut
JAMA. 2016;315(15):1659. doi:10.1001/jama.2016.0312

In Reply We agree with Dr Sanchis-Gomar and colleagues that any dose of exercise is better than physical inactivity and did not intend to discourage individuals from pursuing more exercise. Performance of vigorous exercise is an effective way to reduce the risk for cardiovascular morbidity and mortality.1 However, the dose-response relationship between exercise and cardiovascular health appears to be different for moderate-intensity vs vigorous-intensity activities. Whereas moderate-intensity exercise of 100 min/d or less progressively reduces cardiovascular mortality, vigorous exercise of more than 10 min/d provides little additional benefit.2

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