The truth of the idea that "a multiplicity of remedies advocated for the treatment of any one disease indicates poverty rather than wealth in therapy" is well illustrated by migraine. A hundred miscellaneous "remedies" have been advanced for the treatment of migraine, and still it is largely incurable. The addition of more remedies for migraine merely adds to the embarrassment of riches unless the new remedies throw a ray of light on the essential nature of the condition and make treatment more rational.
Thomas C. Hunt,1 in an article on bilious migraine, reports a reinvestigation by newer methods — bile drainage and cholecystography — of the old and generally abandoned idea that migraine has something to do with biliary disturbance. He concludes that local gallbladder disease or dysfunction is not a cause of migraine but probably rather a result. This does not, however, discourage him from trying bile salts
THE RIDDLE OF MIGRAINE. JAMA. 1934;102(26):2188. doi:10.1001/jama.1934.02750260034012