[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.87.3. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 30, 1934

STANDARDIZATION OF DIGITALIS

Author Affiliations

San Francisco.

JAMA. 1934;102(26):2218. doi:10.1001/jama.1934.02750260064023

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

To the Editor:—  Recent correspondence in The Journal (March 17, p. 862; April 14, p. 1246) regarding the standardization of digitalis leaves impressions that are likely to increase the dilemma of manufacturers.Pharmacologists are largely responsible for introducing, and carrying on the principal investigations in, bio-assays, but the practice of bio-assay is chiefly the concern of manufacturers of pharmaceutic products. The latter require simple, reasonably accurate and economical methods that will give reproducible results. Such methods will increase the popularity and promote the use of bio-assays.There is no doubt of the frog method being simple, but there is serious doubt of its giving accurate and dependable results. Moreover, frogs are practically unobtainable in arid and semitropical regions and importations are costly, so that an assay on frogs may actually be more expensive than on cats. However, cats too are difficult to obtain in sufficient quantities almost everywhere. Of course,

First Page Preview View Large
First page PDF preview
First page PDF preview
×