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June 30, 1934

Studies on Gonadotropic Hormones from the Hypophysis and Chorionic Tissue with Special Reference to Their Differences

Author Affiliations

By Christian Hamburger. Acta pathologica et microbiologica Scandinavica. Supplementum XVII. Paper. Pp. 184, with 33 illustrations. Copenhagen: Levin & Munksgaard, 1933.

JAMA. 1934;102(26):2224. doi:10.1001/jama.1934.02750260070031

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This excellent monograph is a record of the author's experimental studies carried out during 1930-1933 in the University Institute for General Pathology, Copenhagen, on materials from exclusively human sources; it was translated from the Danish by Dr. Hans Andersen. The experimental work has been comprehensive, the facts rigorously separated from theory, and the deductive part developed in an apparently reasonable manner; the world literature on the subject is treated satisfactorily but not exhaustively.

Dr. Hamburger's principal thesis is that whereas urines of normal men and women do not contain gonad-stimulating substances demonstrable by simple injection of the urine into immature female rats and mice, the urines of castrated men and women do contain such substances in relatively large amounts (confirming the observations of Fluhmann in 1929). The gonad-stimulating substances of castrate urines, however, are different from those contained in the urines of pregnancy.

Routine methods of injecting untreated urines, or

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