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In this short manual the author reviews the theories on acidosis and alkalosis in infancy and points out the practical application in various clinical conditions. Examinations of the alkali reserve of the blood and acidity of the urine in pyloric stenosis, acute renal insufficiency and other conditions are given, with examples. The author advises the administration of sodium chloride in hydrochloremia and the injection of sodium bicarbonate in hypochloremia. The author explains that simple blood determinations will indicate whether sodium chloride or sodium bicarbonate is indicated, but there are probably many other physiologic factors involved, and the whole mechanism is more complicated than the author assumes.
L'acidose et I'insuffisance rénale aiguë chez le nourrisson. JAMA. 1934;102(26):2225. doi:10.1001/jama.1934.02750260071036