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March 14, 1931

The Effect of Quinine on the Production of Gametocytes in Subtertian Malaria.

JAMA. 1931;96(11):889. doi:10.1001/jama.1931.02720370067042

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Forty patients having gametocytes in their blood on admission to the hospital were given 2 Gm. of quinine hydrochloride daily and were observed for seven days or longer. A comparison of this series with another one consisting of forty patients treated similarly but without quinine treatment indicates that quinine does not affect the production of gametocytes. This conclusion is corroborated by a third series in which the gametocyte content of the patients' blood was estimated for several days before treatment and compared with the gametocyte content after treatment with quinine.

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