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July 7, 1934


JAMA. 1934;103(1):30-31. doi:10.1001/jama.1934.02750270032013

Tyrosine is one of the long known amino acids derived from the breakdown of proteins. It is liberated in the digestive tract through the digestion of the albuminous foods and is readily conceivable as a product of the disintegration of protein in tissues whenever this occurs. Several amino acids may appear in the urine in any condition in which there is extensive tissue destruction. This explains the report of the occurrence of tyrosine in the urine as early as the middle of the last century by Frerichs and Städeler,1 when they observed this amino acid in a case of acute yellow atrophy of the liver. The appearance of tyrosine in the urine was subsequently reported by a number of clinical observers, but there is little doubt that some of these reports were cases of mistaken identity.2 Consequently the view gradually developed that the frequency and amount of tyrosine

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