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Comment & Response
April 26, 2016

TP53 Gene and Cancer Resistance in Elephants

Author Affiliations
  • 1Division of Hematology/Oncology, University of Kansas Medical Center, Kansas City

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2016;315(16):1789-1790. doi:10.1001/jama.2016.0446

To the Editor Dr Abegglen and colleagues1 confirmed a low cancer incidence in elephants and hypothesized that this relates to increased genomic protection by p53, possibly due to high copy numbers (20-40) of transcribed p53 pseudogenes. Also, peripheral lymphocytes and fibroblasts in elephants showed greater apoptotic sensitivity to ionizing radiation or doxorubicin than similar cells from humans.

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