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To the Editor:—
In following the cases in which the use of dinitrophenol has been reported, in The Journal and elsewhere, it has seemed to us that not enough emphasis has been placed on the regulation of the dosage with relation to the external temperature. A dosage of 300 mg. daily has been given as reasonable by Tainter and others, when the patient has become habituated to the drug by lesser doses, starting at about 100 mg. daily. From observation, we have come to believe that when the external temperature is above 80 F. this dosage is likely to cause discomfort to the patient, with excessive sweating and a possible rise in body temperature. We would suggest that, during the time such temperatures prevail, the dosage be cut to about 50 per cent of what the individual tolerates well in cooler weather.
Cope OM, Coombs HC. DINITROPHENOL AND EXTERNAL HEAT. JAMA. 1934;103(1):60. doi:10.1001/jama.1934.02750270062024