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March 21, 1931


JAMA. 1931;96(12):948. doi:10.1001/jama.1931.02720380036013

Most physicians are accustomed to assume that menstruation is in some way connected with ovulation in women, or, more specifically, with the fate of a liberated ovum. If the ovum is fertilized and implanted, menstrual changes are averted. Corner1 has pointed out that the heart of the difficulty in understanding some of these fundamental features of the reproductive cycle in man obviously lies in ignorance of the time relation of ovulation and implantation with respect to menstruation. It is not known, by any direct observation, he states, when the primate ovum is discharged; the unfertilized ovum has never been observed after leaving the ovary, nor has the fertilized egg been seen early enough to give any information with regard to the earliest stages of implantation; i. e., during the first two weeks. In the lower forms the phenomenon of estrus with its sharply defined period serves as a clue

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