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The authors represent one of three groups of investigators which independently of one another showed that the bleeding tendency of patients with obstructive jaundice could be prevented by treatment with vitamin K. They have also played an important part in the demonstration of vitamin K deficiency in connection with certain intestinal disorders. The book gives a survey of their own work in this field, in which they have had considerable clinical experience, and a brief reference to the work of other investigators. It further contains an attempt to give a general orientation about the other problems concerning vitamin K, biologic, chemical and clinical. The parts of the book which deal with the history of the work done at the Mayo Clinic are by far the most detailed. Most interesting to read are perhaps the historical notes of the bleeding tendency of jaundiced patients, dating back to Georg Wolfgang Wedels in
Vitamin K. JAMA. 1941;117(19):1657. doi:10.1001/jama.1941.02820450081032