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Article
July 28, 1934

THE SUGAR TOLERANCE IN SIBLINGS OF JUVENILE DIABETIC PATIENTS

Author Affiliations

NEW YORK
From the Children's Diabetic Clinic, service of Dr. Béla Schick, Mount Sinai Hospital.

JAMA. 1934;103(4):240-242. doi:10.1001/jama.1934.02750300014005
Abstract

It is generally accepted that diabetes mellitus is a familial or hereditary disorder of metabolism. In fact, Pincus and White1 have been able statistically to show that diabetes is inherited as a mendelian recessive characteristic. Experimental proof of this fact has been brought forward by Cammidge.2 He was able, by mating strains of mice having a high fasting blood sugar with those having normal blood sugars, to transmit the hyperglycemia to succeeding generations as a recessive quality. Cammidge suggested that in human beings the same blood sugar conditions might occur. Joslin and his co-workers3 have shown that new cases of diabetes mellitus are continually being encountered in the families of diabetic children. They have shown a progressive incidence in new cases in those families from year to year.

Because of the familial tendency of diabetes, a study was started in 1928 with the purpose of detecting early

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