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This small volume on morphinism is written from the clinical point of view. It goes with considerable detail into the clinical causes, means, symptoms, course and treatment of chronic morphinism. The fundamental pharmacology of the condition is not discussed in anything like a thorough manner, the reader being referred to such works as Heffter's Handbuch. Hahn gives a rather inclusive list and brief description of native and artificial opium alkaloids which is useful to one interested in this field. A useful but relatively brief bibliography is also given. Hahn divides the course of chronic morphinism into three stages: (1) the stage of induction or developing tolerance, (2) the stage of equilibrium and (3) the stage of intolerance. In the last, or third, stage the subject does not obtain the usual desired results, such as depression and euphoria, but is rendered more irritable. It is in this stage that he is
Die Morphin-Erkrankungen.. JAMA. 1927;89(22):1895-1896. doi:10.1001/jama.1927.02690220071038