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To the Editor:—
I enjoyed reading the editorial on the estimation of vitamin C in The Journal, June 2. May I call your attention to one sentence in the first paragraph, which states that vitamin C is clearly recognized as one of the hexuronic acids. This is, I believe, an error of chemical description.
Our correspondent is quite correct in pointing out that ascorbic acid, now identified with vitamin C, can no longer be regarded as one of the hexuronic acids, since its structure has been clearly demonstrated. E. H. Farmer (Annual Reports on the Progress of Chemistry for 1933, p. 167) says: "Szent-Györgyi's compound is not a member of the uronic acid class and has been renamed ascorbic acid." This statement is evidently based on an article by Haworth and Szent-Györgyi (Nature131:24, 1933) in which it appears that in view of the fact that (1) hexuronic
ESTIMATION OF VITAMIN C. JAMA. 1934;103(4):276. doi:10.1001/jama.1934.02750300050025