December 10, 1927


JAMA. 1927;89(24):2053-2054. doi:10.1001/jama.1927.02690240045023

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An Abnormal Type of Influenza  Drs. Carrière and Auguste of Lille have reported in their city the existence of a grave infectious and epidemic disease that presents peculiar characteristics. The onset of the disease, which is attended with a rapid rise of temperature, sharp pains in the legs and more particularly in the calves, deep prostration and gastro-intestinal disorders, resembles that of severe cases of influenza. Later, these symptoms are aggravated and are associated with a white edema, which affects at first the face and later the malleolar region, spreading to the thighs, the trunk, and sometimes even to the upper limbs. The third week brings usually multiple neuritis together with motor paralysis, especially of the lower limbs. The fourth week, the fate of the patient is determined: either the persistence of this complex pathologic condition and a fatal termination, or a fall in the temperature, retrogression of the edemas,

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