The effective treatment of sprue is a problem of considerable practical importance in spite of the fact that therapeutic methods which are occasionally successful have been at hand for many years. One serious difficulty lies in the fact that different individuals, presenting an apparently identical clinical picture, manifest wide variations in the amount of specific therapy that they require to effect clinical cure. Moreover, the available information regarding the treatment of sprue is confusing, since the various therapeutic procedures in use appear to be so unrelated and the clinical results obtained from them have been so inconstant that it has seemed impossible to draw up a general rule of treatment that would be applicable to all cases.
More detailed analysis of the existing therapeutic methods in the light of present knowledge makes it clear that a general rule of treatment can be formulated and, furthermore, that from the therapeutic results
RHOADS CP, MILLER DK. INTENSIVE LIVER EXTRACT THERAPY OF SPRUE. JAMA. 1934;103(6):387-391. doi:10.1001/jama.1934.02750320005003