A great number of articles in the literature from 1910 until the early 1930's attest the value of intraspinal methods in the treatment of neurosyphilis. However, since the advent and ensuing favor of various other measures, this method of therapy gradually has been discarded by many syphilotherapists and we think unjustifiably so.
In appraisal of the methods of treatment dealt with in three papers from the Cooperative Clinical Group,27 it must be remembered that the various forms of supplemental therapy in general were used only after routine therapy had failed and many of the patients had more than one type of supplemental treatment. The conclusions that were reached in the aforementioned papers, therefore, do not constitute a true comparative evaluation of the symptoms of treatment but rather constitute contrast of one method with another when simpler methods failed to produce the desired clinical and serologic results. For example, a comparison
KIERLAND RR, O'LEARY PA. INTRASPINAL THERAPY OF NEUROSYPHILIS. JAMA. 1941;117(24):2035–2042. doi:10.1001/jama.1941.02820500017004