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Comment & Response
June 7, 2016

Treatment for Patients With Newly Diagnosed Glioblastoma—Reply

Author Affiliations
  • 1Department of Oncology, University Hospital Zurich, Zurich, Switzerland
  • 2Department of Neurosurgery, Geisinger Health System, Danville, Pennsylvania
  • 3Department of Translational Neuro-Oncology and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California
JAMA. 2016;315(21):2348-2349. doi:10.1001/jama.2016.1847

In Reply Tumor-treating fields are a novel approach to the treatment of cancer. In vitro and animal studies have demonstrated that the use of alternating electrical fields, at a frequency specifically tuned to penetrate tumor cells, interferes with microtubule formation, proper localization of the cytokinetic contractile ring, and chromosomal segregation, leading to cell cycle arrest, apoptosis, and reduced clonogenic potential.13 Little progress has been made in the treatment of glioblastoma over the last decade, yet our study demonstrated a significant improvement in both progression-free and overall survival in patients with glioblastoma.

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