Carcinoma of the small bowel is often considered extremely rare. Though it is not common it is more frequent than is usually supposed. Sarcoma, however, is found more often in the lower part of the ileum than in the large bowel. Cancer of the ampulla of Vater and its adjoining tissue increases the incidence of carcinoma of the duodenum.
Three types of carcinoma of the jejunum and of the ileum may be considered: (1) the most common, adenocarcinoma; (2) carcinoid, or argentaffin tumor, and (3) melanocarcinoma.
The paper by Rankin and Mayo1 in 1930, a later paper by Rankin and Newell2 in 1933 and Raiford's3 articles on tumors of the small intestine in 1931 and 1932 were thorough and interesting. They included reports on tumors of the small bowel occurring almost to the time of publication of the reports. Few cases have been added to the literature
HORSLEY JS. CARCINOMA OF THE JEJUNUM AND OF THE ILEUM. JAMA. 1941;117(25):2119-2123. doi:10.1001/jama.1941.02820510007002