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April 4, 1931


JAMA. 1931;96(14):1147. doi:10.1001/jama.1931.02720400045015

The customary discussions of acquired immunity or resistance to harm refer to the phenomena that are conspicuous in the course of infectious diseases. The physiologic activity of body cells may be promoted so as to aid in the elimination of toxic products. Substances that counteract toxins or damage infectious agents may be generated in the organism. Wandering leukocytes of the infected host may become more abundant and more active. MacNider1 has recently pointed out, however, that the resistance which may develop in the higher animals against certain drugs and chemical poisons cannot be explained by any of the mechanisms mentioned. His studies at the University of North Carolina point to the possibility of an entirely different principle being involved in the acquired tolerance to noxious agents. It is well known2 that uranium in the form of one of its salts is one of the oldest substances to be

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