Nearly 2 dozen cases of a rare but serious skin reaction linked over the past 20 years with the antipsychotic medication olanzapine have prompted a warning from the FDA.
The agency will add information to drug labels for all olanzapine-containing products warning that they may cause drug reaction with eosinophilia and systemic symptoms (DRESS), which can start as a rash that sometimes spreads across the entire body. Fever, swollen lymph nodes, and a swollen face may accompany the rash. The condition results in a higher-than-normal number of eosinophils that can cause inflammation or swelling. In severe cases, damage to organs including the liver, kidneys, lungs, heart, or pancreas may occur.
Voelker R. Olanzapine Linked With Potentially Fatal Skin Reaction. JAMA. 2016;315(23):2514. doi:10.1001/jama.2016.7382