In Reply The ASTIC trial was designed to investigate the possibility, suggested by a number of case reports, that long-term, drug-free cure of Crohn disease could be achieved through autologous HSCT.1 The lack of statistical significance of the primary end point showed that this experience is rare. However, we agree with Dr Burt and colleagues that the extent of improvement in secondary end points suggests possible therapeutic efficacy, albeit falling short of cure.
Hawkey CJ, Lindsay J, Gribben J. Stem Cell Transplantation for Refractory Crohn Disease—Reply. JAMA. 2016;315(23):2620-2621. doi:10.1001/jama.2016.4033