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Comment & Response
June 21, 2016

Stem Cell Transplantation for Refractory Crohn Disease—Reply

Author Affiliations
  • 1Nottingham Digestive Diseases Center, University of Nottingham, Nottingham, United Kingdom
  • 2Blizard Institute, Barts and the London School of Medicine, London, United Kingdom
  • 3Barts Cancer Institute, Barts and the London School of Medicine, London, United Kingdom
JAMA. 2016;315(23):2620-2621. doi:10.1001/jama.2016.4033

In Reply The ASTIC trial was designed to investigate the possibility, suggested by a number of case reports, that long-term, drug-free cure of Crohn disease could be achieved through autologous HSCT.1 The lack of statistical significance of the primary end point showed that this experience is rare. However, we agree with Dr Burt and colleagues that the extent of improvement in secondary end points suggests possible therapeutic efficacy, albeit falling short of cure.

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