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This is essentially a report of the results obtained in studies carried out to determine the relationship between bacterial infection and the formation of gallstones. The study was undertaken because it was noted that the center of gallstones was made up of necrotic-like epithelial cells and that, in the walls of gallbladders in which recent formation of stone had taken place, sporulating bacilli occurred intraepithelially and subepithelially with surrounding regions of necrosis and desquamating epithelium.
Considerable space is given to a general consideration of cholelithiasis. The composition and structure of gallstones is reviewed in detail, and a method is presented for analyzing the stroma of the gallstone without injuring possible existent bacteria. A chapter is devoted to the symptomatology and pathology of gallstones. The various theories of the etiology of gallstones are reviewed in detail, and attention is drawn to the possible connection between the formation of gallstones and systemic
Studies on the Etiology of Gallstones: A Subtilis-Like Bacilli-Group as an Etiologic Factor. JAMA. 1941;117(26):2291. doi:10.1001/jama.1941.02820520087037