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December 27, 1941

Über funktionelle Veränderungen der P- und T-Zacken im Elektrokardiogramm: Experimentelle Untersuchungen mit Ergotamin und Amylnitrit, sowie klinische Beobachtungen

JAMA. 1941;117(26):2292. doi:10.1001/jama.1941.02820520088039

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In this extensive monograph with an English summary the author presents his investigations on the changes in the electrocardiogram due to certain functional disorders. He first reports on the effects of posture change from lying to standing in 49 subjects before and after the injection of 0.5 mg. of ergotamine. This included 14 patients with orthostatic hypotension. In all subjects, but more marked in the orthostatic patients, definite changes in the electrocardiogram appeared. Ergotamine was found to lessen noticeably the postural alterations in the electrocardiogram. This suggested that the action of posture change does not operate through the production of coronary insufficiency but through a direct action on the heart, reflex in origin and sympathicotonic in character. The author then relates his experience with the inhalation of amyl nitrite by 21 normal young persons and by an older person with complete heart block. Again changes in the electrocardiogram were found

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