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Comment & Response
June 28, 2016

Prenatal Vitamin D and Offspring Wheezing

Author Affiliations
  • 1Department of Noncommunicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • 2Medical Statistics Department, London School of Hygiene and Tropical Medicine, London, United Kingdom
JAMA. 2016;315(24):2730. doi:10.1001/jama.2016.4108

To the Editor Dr Litonjua and colleagues reported the results of a randomized clinical trial investigating the effect of prenatal supplementation with vitamin D on asthma and wheezing in young offspring.1 The study provides an example of the problems with so-called “statistical significance” and the interpretation of P values with reference to an arbitrary threshold. The authors estimated that high-dose vitamin D given in pregnancy was associated with a reduced risk of the coprimary outcome of recurrent wheeze (hazard ratio [HR], 0.8 [95% CI, 0.6-1.0]), with an associated P value of .051.

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