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This monograph deals with undulant fever of the bovine variety; that is, caused by Brucella abortus of bovine type. The causative organism is discussed together with its morphologic and cultural characteristics; also immune reactions and effects on animals, the epidemiology, the clinical manifestations, diagnosis, prognosis and treatment, and the pathologic anatomy of undulant fever. One obtains a good summary of the recent European observations on the disease. The most interesting chapter is the one on the pathologic anatomy, concerning which but little has been learned so far as the human infection is concerned. In guinea-pigs Brucella abortus causes granulomatous changes, especially in the spleen. Löffler describes and illustrates the changes in the spleen in a subchronic case of undulant fever. The spleen contained numerous small granulomatous foci, diffuse inflammatory changes, and a peculiar chronic endophlebitis. The spleen was excised during life and at the same time a bit of liver
Febris undulans Bang des Menschen.. JAMA. 1931;96(14):1173. doi:10.1001/jama.1931.02720400071041