To the Editor Dr Faisy and colleagues randomized mechanically ventilated patients with chronic obstructive pulmonary disease (COPD) to test the effect of acetazolamide vs placebo on the duration of mechanical ventilation (primary end point).1 They failed to demonstrate a statistically significant benefit of acetazolamide, although it was associated with a 16-hour reduction in mechanical ventilation duration (P = .17). Thirty percent of the patients received loop diuretics at baseline, but the proportion with loop diuretics prescribed during the trial was not provided.
Contou D, de Prost N, Dessap AM. Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD. JAMA. 2016;316(1):99-100. doi:10.1001/jama.2016.4619