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Comment & Response
July 5, 2016

Acetazolamide and Invasive Mechanical Ventilation for Patients With COPD

Author Affiliations
  • 1Service de Réanimation Médicale, Hôpital Henri Mondor, Créteil, France
JAMA. 2016;316(1):99-100. doi:10.1001/jama.2016.4619

To the Editor Dr Faisy and colleagues randomized mechanically ventilated patients with chronic obstructive pulmonary disease (COPD) to test the effect of acetazolamide vs placebo on the duration of mechanical ventilation (primary end point).1 They failed to demonstrate a statistically significant benefit of acetazolamide, although it was associated with a 16-hour reduction in mechanical ventilation duration (P = .17). Thirty percent of the patients received loop diuretics at baseline, but the proportion with loop diuretics prescribed during the trial was not provided.

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