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September 1, 1934

Einige Carcinome und Adenome beim Menschen: Ferner vom Krebs bei Tieren und "in Vitro."

JAMA. 1934;103(9):706-707. doi:10.1001/jama.1934.02750350070033

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The author develops the theory previously expressed in his "Grundlage der Geschwulstlehre" concerning the development of cancer by purely mechanical strain (including in this inflammation and chemical influences) on tissue. This results in a displacement of the previous activity of the cell to a higher level, which is expressed in an enlargement of the entire cell or some part of it relative to normal dimensions. He admits also certain tissue predisposition that synergizes the external stimulus. He pleads for the abandonment of previous concepts of tumor classification based on the characteristics of the tumor tissue as a whole (i. e., faulty differentiation or forgotten embryonal cells) in favor of one based on actual microscopic measurement. He feels definitely that the cancer cell is a unique thing. To demonstrate his theory further he offers tables having the nuclear length in micromillimeters as one coordinate and the various tumors graded or classified

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