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September 8, 1934


JAMA. 1934;103(10):756. doi:10.1001/jama.1934.02750360032015

As the principal component of the solid matter of protoplasm and of much of the intercellular material of tissue is protein, the body must depend to a considerable extent on this nitrogenous material for its growth and maintenance. The proteins of the tissues are synthesized from the assortment of amino acids that accumulate in the cellular and intercellular fluids during the hours immediately following a meal containing protein. These synthetic products appear to be characteristic for each tissue of an animal. For example, hemoglobin, the so-called respiratory protein of the blood, will differ in its amino acid make-up from the protein of the muscle. The mechanism by which each tissue selects particular amino acids in the right proportion to form its own specific nitrogen-containing complexes is unknown, but recent investigations have strikingly supported the remarkable specificity manifested by the mammalian organism in these biochemical processes. Attention has been drawn to

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