[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 5,290
Citations 0
July 12, 2016

Antiretrovirals for HIV Treatment and PreventionThe Challenges of Success

Author Affiliations
  • 1The Fenway Institute, Fenway Health, Boston, Massachusetts
  • 2Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
  • 3Department of Medicine, Harvard Medical School, Boston, Massachusetts
JAMA. 2016;316(2):151-153. doi:10.1001/jama.2016.8902

After the first case reports of AIDS were described in 1981, it soon became clear that the epidemic constituted a public health emergency. Although the first antiretrovirals were evaluated in clinical trials in the 1980s, it was not until the mid-1990s that the clinical efficacy of combination antiretroviral chemotherapy was demonstrated to prevent immunocompromise and to restore health to people living with AIDS. When the International Antiviral Society–USA (IAS-USA) published its first antiretroviral guidelines in JAMA in conjunction with the International AIDS Conference in Vancouver in 1996,1 it represented the beginning of a new era, suggesting that the pandemic might be controlled by treatment. In the current issue of JAMA, the IAS-USA presents its most recent set of guidelines,2 reflecting substantial changes over the past 20 years in the development of more potent combinations of drugs with fewer adverse effects, the advent of coformulated medications, and the evidence that antiretroviral agents have a vital role in HIV prevention.

First Page Preview View Large
First page PDF preview
First page PDF preview