A survey of the clinical course of eight patients with pernicious anemia and spinal cord degeneration indicates that they may be divided sharply into a group of four that have shown no neurologic progress and a like number that have grown steadily worse. The period of observation in five of these cases is more than three years; the others have been followed from one and a half to two and a half years.
The determination of the effect of liver treatment on funicular myelosis in pernicious anemia is of the greatest importance. The hematopoietic remission with liver occurs so readily that it is probable that the majority of these anemic patients will be preserved by it from death in anemia. Yet, if cord degeneration is not preventable by the same means, over 80 per cent1 of these might develop it with its prolonged disability, painful symptoms and ultimate death
STARR P. THE PREVENTION OF SPINAL CORD DEGENERATION IN PERNICIOUS ANEMIA. JAMA. 1931;96(15):1219–1221. doi:10.1001/jama.1931.02720410029010