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JAMA Clinical Guidelines Synopsis
July 19, 2016

Clinical Management of Opioid Use Disorder

Author Affiliations
  • 1Northwestern University, Chicago, Illinois
  • 2University of Chicago, Chicago, Illinois
JAMA. 2016;316(3):338-339. doi:10.1001/jama.2016.9795

Death caused by drug overdose is a major problem in the United States. In 2014, nearly 29 000 people died of opiate overdose.1 Underlying this trend is a parallel increase in opioid use disorder, defined as a problematic pattern of opioid use leading to clinically significant impairment or distress. Opioid use disorder contributes to significant mortality, primarily from overdose, as well as morbidity.

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