Death caused by drug overdose is a major problem in the United States. In 2014, nearly 29 000 people died of opiate overdose.1 Underlying this trend is a parallel increase in opioid use disorder, defined as a problematic pattern of opioid use leading to clinically significant impairment or distress. Opioid use disorder contributes to significant mortality, primarily from overdose, as well as morbidity.
Dunlap B, Cifu AS. Clinical Management of Opioid Use Disorder. JAMA. 2016;316(3):338-339. doi:10.1001/jama.2016.9795