In a previous paper the histologic changes in seventy-five cases of chronic cervicitis as revealed by serial sectioning were described.1 In six of these, blastomatoid changes consisting of cellular and nuclear deviations in size, shape and chromatism, epithelial heterotopia and stroma reaction were present. We designated these changes as neoplasia. It was made clear that it was imperative to follow up the patients in whom this neoplasia was found, to determine the significance of the cellular changes. To these six cases, in the course of time, three more were added, so that we have now nine cervices with blastomatoid changes. Eight were treated immediately with adequate doses of radiation as used in carcinomas, and normal anatomic conditions were obtained. One patient was not treated and a report of the case will now be given:
Jan. 30, 1933, a low circular amputation of the cervix of Mrs. S. was done.
SCHMITZ H, BENJAMIN EL. THE EARLY HISTOLOGIC DIAGNOSIS OF CARCINOMA OF THE UTERINE CERVIX. JAMA. 1934;103(11):808-810. doi:10.1001/jama.1934.02750370012003