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Article
September 15, 1934

THE PATHOLOGIC CHANGES OF THE ST. LOUIS TYPE OF ACUTE ENCEPHALITIS

JAMA. 1934;103(11):822-825. doi:10.1001/jama.1934.02750370026006
Abstract

A large number of autopsies was secured during the recent St. Louis epidemic of acute encephalitis, the result mainly of the cooperation of the various public health offices, the general medical profession and the public. Sufficient material was obtained for a complete study of sixty-three cases. The thoracic and abdominal organs and portions of the spinal cord were examined in addition to the brain in about 90 per cent of the autopsies. An adequate neuropathologic study of all this material has not yet been accomplished, but a few representative cases have been studied in detail and a sufficient number of sections from the others have been examined to obtain a fair understanding of the pathologic alterations in this type of encephalitis. The essential pathologic process is an acute nonsuppurative inflammation of the central nervous system characterized by severe vascular congestion with occasional petechial hemorrhages, cellular infiltration of the nervous tissue

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