The universal necessity of water for biologic processes is generally recognized; the consequences of deprivation of this medium in which the chemical changes of metabolism occur are not so clearly appreciated. In discussing the water balance of the body, Rowntree1 has pointed out that for the maintenance of health the intake must be sufficient to maintain the amount of water in the body tissues necessary for maximal efficiency in metabolism and in the execution of other physiologic processes. This involves the removal of waste products and the dissipation of heat. A certain degree of desiccation of various organs, tissues and fluids ensues when the amount of water eliminated from the body exceeds the amount ingested, plus that produced through metabolic processes. The untoward consequences of such situations have only begun in recent years to receive the serious consideration they deserve.
The blood tends to maintain its integrity of composition
BLOOD CONCENTRATION AND ITS TREATMENT. JAMA. 1928;90(4):295–296. doi:10.1001/jama.1928.02690310047018