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April 11, 1931

Cancer: Its Origin, Its Development and Its Self-Perpetuation: The Therapy of Operable and Inoperable Cancer in the Light of a Systemic Conception of Malignancy. A Research.

JAMA. 1931;96(15):1255. doi:10.1001/jama.1931.02720410065039

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This book, which is based on literary research and on philosophic reflection, is divided into two parts, the first dealing with the origin, development and self-perpetuation of cancer, the second with the treatment of cancer in the light of a systematic conception of malignancy. The first part has twenty-nine chapters, all of which have been published before in various periodicals under the heading "Some Notes on Cancer." All these articles have been revised and expanded. The second part is wholly new and deals mainly with the remedial effects in cancer of fever and of acidosis. There are portraits of ten scientists, all dead, whose work has influenced research in cancer. The word "cancer" is used to include every kind and type of malignant new growth. The author's thesis is that "cancer appears as a systemic disease, more particularly as the joint effect of two simultaneously active chronic irritations, the one

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