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To the Editor:
—In The Journal, Dec. 17, 1927, the question is asked as to the present status of the single dose immunization against scarlet fever with ricinoleated toxin. In the reply the statement is made that "it is hardly to be expected that the addition of a 'detoxifying' agent will increase the immunizing properties of a toxin." This statement, I believe, is misleading.The purpose of a detoxifying agent is not to step up the immunizing properties of a toxin but rather to make it possible to give toxin in sufficient dosage to stimulate immunization processes. The antitoxin in the toxin-antitoxin mixtures used to immunize against diphtheria is nothing other than a detoxifying agent. Without the use of antitoxin it would be impossible to give diphtheritic toxin in sufficient dosage to stimulate immunity, because of the severe reaction that would result. The anatoxin of Ramon as well as toxoid
Larson WP. SINGLE DOSE IMMUNIZATION AGAINST SCARLET FEVER. JAMA. 1928;90(4):312. doi:10.1001/jama.1928.02690310064033