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January 28, 1928

Conditioned Rflexes. An Investigation of the Physiological Activity of the Cerebral Cortex.

JAMA. 1928;90(4):317. doi:10.1001/jama.1928.02690310069044

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This monumental work is an almost stenographic report of a series of lectures delivered at the military medical academy in Petrograd, in which the author attempted to give a full and systematic exposition of the researches on the activity of the cerebral hemispheres in the dog that were made in the laboratory in the course of twenty-five years. After describing the methods of establishing conditioned reflexes of various degrees of complexity, the author exposes, by numerous examples, the irradiation and concentration of excitatory and inhibitory processes that make the activity of the cerebrum so complex. Sleep, according to Pavlov, is nothing but an irradiation of inhibition from a certain point to the entire cortex. The varied and sometimes unusual behavior of some of the dogs is ascribed to pathologic disturbances of the cortex, developed through functional interference, intentional on the part of the experimenter or accidental as a result of

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