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The authors present a crystallized concept of the mechanism of blood coagulation as a basis for further investigative work. They do not intend this discussion as a finished review but present it merely as a summary for those interested in the scientific aspect of the subject. The authors have had a wide experience with the clinical and experimental phases of blood coagulation but present the subject in a most unbiased manner. Speculation has been avoided and no conclusions are drawn along one line of investigation. The work is divided as follows: 1. Short historical survey of all the theories on blood coagulation. 2. Physiologic consideration of the elements entering into the mechanism of blood coagulation. 3. Discussion of some of the clinical conditions characterized by an alteration in the coagulability of the blood. 4. Summary. The work will be of interest chiefly to those interested in the mechanism of blood
Die Physiologie und Pathologie der Blutgerinnung.. JAMA. 1931;96(15):1257. doi:10.1001/jama.1931.02720410067048