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Using sophisticated modeling approaches to track spatiotemporal abnormalities associated with late-onset Alzheimer disease, researchers have found that vascular dysregulation may be the earliest and strongest brain pathologic factor associated with development of the disease (Iturria-Medina Y et al. Nat Commun. 2016;7:11934).
Investigators analyzed more than 7700 brain images obtained by 5 different imaging modalities and several different plasma and cerebrospinal fluid biomarkers from a total of 1171 healthy individuals and patients with late-onset Alzheimer disease. By comparing imaging and biological markers in healthy and pathological aging, they determined that the pathologic factors following vascular dysregulation in strength of spatiotemporal abnormality were amyloid-β deposition, glucose metabolism dysregulation, functional impairment, and gray matter atrophy.
Hampton T. Vascular Dysfunction an Early Contributor to Alzheimer Disease. JAMA. 2016;316(5):484. doi:10.1001/jama.2016.10010