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Comment & Response
August 2, 2016

Early Antibiotic Exposure and Childhood Weight Gain

Author Affiliations
  • 1Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
JAMA. 2016;316(5):541. doi:10.1001/jama.2016.7300

To the Editor Dr Gerber and colleagues assessed the association between antibiotic exposure during the first 6 months of life and childhood weight gain and concluded that there was no association.1 However, there was a significant difference in weight gain in children exposed to any antibiotic in the first 24 months of life (P = .001). The subanalyses showed that this difference was significant in children who received only 1 antibiotic course (P = .01) but was greater in those who received 2 courses (P = .02) and even greater in those exposed to 3 or more courses (P = .002). Can the authors comment on these findings and explain why they did not consider these significant differences in their discussion?

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