Amenorrhea may be a symptom of a general disease (diabetes, tuberculosis) but usually is of endocrine origin. As these conditions are often seen by the general practitioner, it is important for them to become acquainted with a simplified form of treatment. The tests for making clinical and hormone studies in these cases are frequently not at his disposal and therefore it is my aim in this paper to suggest a simplified method for producing bleeding in amenorrheic women.
The absence of menstrual bleeding is the cause of much concern to women. They suffer psychically and often an inferiority complex develops. The associated nervous and vasomotor disturbances frequently prevent these patients from attending their daily duties. As long as one is unable to put the motor of ovarian function into action, by means of gonadotropic stimulation therapy, one has to try at least to produce bleeding with normal substitution therapy. It
ZONDEK B. SIMPLIFIED HORMONAL TREATMENT OF AMENORRHEA. JAMA. 1942;118(9):705–707. doi:10.1001/jama.1942.02830090023006