February 18, 1928


JAMA. 1928;90(7):546-547. doi:10.1001/jama.1928.02690340048020

In 1924 a brief editorial survey of progress in the search for the cause of measles1 indicated that little real advance had been made since the classic experiments of Hektoen2 in 1905. In his experiments, typical measles had been produced in two persons by injections of small amounts of blood drawn from measles patients on the first day of the rash and incubated twenty-four hours in ascites broth. It had previously been shown that the disease could be produced experimentally by inoculations of fresh nasal mucus and scrapings of the skin containing blood and epithelial débris from measles patients early in the eruptive stage.3

Much has been added in the last three years to the already voluminous literature on the problem of the cause of measles. Tunnicliff and her co-workers have brought forward new facts about the green producing diplococcus which she isolated from the nose, throat

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