[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.166.112.64. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
October 20, 1934

ESTRIN IN HIGH CONCENTRATION YIELDED BY A FIBRO-ADENOMA OF THE BREAST

Author Affiliations

Baltimore
From the Department of Surgery (Surgical Pathological Laboratory), Johns Hopkins Hospital and University.

JAMA. 1934;103(16):1212-1213. doi:10.1001/jama.1934.72750420001007
Abstract

Diffuse and localized hypertrophy of the breast occurs relatively frequently in both the male and the female. In gynecomastia the hypertrophy may be unilateral or bilateral, but it is usually diffuse. The unilateral type is the more common. The localized change (the so-called fibro-adenoma) is the most common form in the female breast. Diffuse hypertrophy of one or both breasts, known as virginal hypertrophy, is most frequently bilateral. Gynecomastia, fibro-adenoma, and virginal hypertrophy are in almost all instances benign. In extremely rare instances a fibrosarcoma is supposed to have developed in or from a preexisting clinically benign fibro-adenoma.

Histologically these benign lesions are characterized by an increase in the length and diameter of the ducts, an increase in the number of layers of epithelium lining the ducts, and a proliferation of the periductal connective tissue. The histologic picture is essentially an exaggeration of that observed in the normal female breast

First Page Preview View Large
First page PDF preview
First page PDF preview
×