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Article
April 25, 1931

THE INTRACAROTID METHOD OF TREATMENT FOR MENINGITIS WITH RECOVERIES

Author Affiliations

Professor of Pathology and Bacteriology in the Graduate School of Medicine of the University of Pennsylvania and Member of the Research Institute of Cutaneous Medicine PHILADELPHIA
From the Research Institute of Cutaneous Medicine of Philadelphia and the Diagnostic Hospital Endowment of the Graduate School of Medicine of the University of Pennsylvania.

JAMA. 1931;96(17):1358-1361. doi:10.1001/jama.1931.02720430008002
Abstract

As reported in a previous communication,1 the intracarotid injection of various serums and chemical agents has been found a safe procedure in the lower animals and has yielded some encouraging results in the treatment of experimental pneumococcus and streptococcus meningitis of dogs, when combined with spinal or cisternal drainage and intracisternal medication.

Dogs infected by the intracisternal injection of young broth cultures of virulent type I pneumococci or highly virulent hemolytic streptococci developed symptoms within twenty-four to thirty-six hours and succumbed within three to six days with all the classic signs of fulminating meningitis, including the characteristic changes in the cerebrospinal fluid.

But from two to six dogs out of each ten with pneumococcus meningitis made complete recoveries when the following treatment was instituted within twenty-four hours after infection and when symptoms of meningitis and spinal fluid changes were first apparent: (a) cisternal drainage; (b) the injection into each

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